Blood-brain barrier in drug discovery : optimizing brain exposure of CNS drugs and minimizing brain side effects for peripheral drugs / edited by Li Di, Pharmacokinetics, Dynamics and Metabolism, Pfizer, Inc., Groton, Connecticut, USA, Edward H. Kerns, Laytonsville, MD, USA
| Material Type | Books |
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| Publisher | Hoboken, New Jersey : John Wiley & Sons Inc. |
| Year | [2015] |
| Size | xiv, 586 pages, 4 unnumbered pages of plates : illustrations (some color) ; 25 cm |
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| Location | Volume | Call No. | Barcode No. | Status | ISBN | Media type | Restriction | Request Memo | Reserve |
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| 第3-1F 閲覧室洋書 | :hpk | 491.5/D 71 | 4000001524 | 9781118788356 | 図書 |
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| Contents | Machine generated contents note: Summary List of Chapters1. Overview/Introduction / Li Di (Pfizer Inc.), Edward H. Kerns (Pharmacokinetics of Brain Exposure)2. Pharmacokinetics of CNS penetration / Andreas Reichel (Bayer)3. Free Drug Hyposthesis for CNS Drug Candidates / Xingrong Liu (Genentech)4. Species Differences and impact of desease state on BBB / Jean-Marie Nicolas (UCB Pharma S.A.)Mechanisms of Drugs Across the Blood-Brain Barrier5. Passive diffusion permeability of the BBB - examples and SAR / Phil Jeffrey (GSK)6. Efflux transport at the BBB - examples and SAR / Jerome Hochman (Merck)7. Uptake transport at the BBB - examples and SAR / Zack Cheng (AstraZeneca)8. Uptake of proteins and antibodies at the BBB / William Pardridge (UCLA)Predicting and Measuring Brain Exposure of Drugs9. In silico tools for assessing brain exposure / Hongming Chen (AstraZeneca)10. In vitro assays for assessing BBB permeability - vascular cells, artificial membranes, brain slice, cell uptake / Winfried Neuhaus (University of / Li Di (Pfizer Inc.), Edward H. Kerns (Pharmacokinetics of Brain Exposure)2. Pharmacokinetics of CNS penetration / Andreas Reichel (Bayer)3. Free Drug Hyposthesis for CNS Drug Candidates / Xingrong Liu (Genentech)4. Species Differences and impact of desea |
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| Notes | Includes bibliographical references and index Summary: "Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most significant - and most challenging - areas of drug discovery. Written by world experts to provide practical solutions to increase brain penetration or minimize CNS side-effects. Reviews state-of-the-art in silico, in vitro, and in vivo tools to assess brain penetration and advanced CNS drug delivery strategies. Covers BBB physiology, medicinal chemistry design principles, free drug hypothesis for the BBB, and transport mechanisms including passive diffusion, uptake/efflux transporters, and receptor-mediated processes. Highlights the advances in modelling BBB pharmacokinetics and dynamics relationships (PK/PD) and physiologically-based pharmacokinetics (PBPK). Discusses case studies of successful CNS and non-CNS drugs, lessons learned and paths to the market"-- Provided by publisher |
| Authors | Di, Li editor Kerns, Edward Harvel editor |
| Subjects | MESH:Blood-Brain Barrier -- metabolism MESH:Central Nervous System Agents -- pharmacokinetics MESH:Blood-Brain Barrier -- drug effects MESH:Central Nervous System Diseases -- drug therapy MESH:Drug Discovery -- methods MESH:Drug-Related Side Effects and Adverse Reactions -- prevention & control |
| Classification | LCC:RM315 NLM:WL 200 DC23:615.7/8 |
| ID | 4000006697 |
| ISBN | 9781118788356 |
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